Role/activity of organisation in the project
JRC is the leader of the subproject (SP) two, that aims to verify the toxicity and biocompatibility of NPs. Moreover, it is involved in biodistribution studies in the framework of SP six
The JRC is testing the basal cytotoxicity of NPs by means of the Colony Forming Efficiency assay on selected cell lines and by means of the viability assay Alamar Blue. Nevertheless, it is testing the interaction of the NPs with the cell culture medium to verify their stability in contact with biological environments.
Key people involved in the project
François Rossi, PhD, responsible for the NanoBiotechnology laboratory at JRC Ispra.
Jessica Ponti, PhD, responsible for the toxicology studies within the NanoBiotechnology laboratory at JRC Ispra.
Valentina Mariani, PhD, post-doc
Guido Giudetti, PhD, post-doc
Rosella Coradeghini, PhD, post-doc
Chiara Uboldi, PhD, post-doc
Patrick Marmorato, PhD student
Recent publications / patents
Ponti J, Colognato R, Rauscher H, Gioria S, Broggi F, Franchini F, Pascual C, Giudetti G, Rossi F. Colony Forming Efficiency and microscopy analysis of multi-wall carbon nanotubes cell interaction.
Toxicol Lett. 2010 Aug 1;197(1):29-37. Epub 2010 Apr 29.
Ponti J, Sabbioni E, Munaro B, Broggi F, Marmorato P, Franchini F, Colognato R, Rossi F. Genotoxicity and morphological transformation induced by cobalt nanoparticles and cobalt chloride: an in vitro study in Balb/3T3 mouse fibroblasts. Mutagenesis. 2009 Sep;24(5):439-45. Epub 2009 Jul 15.
Colognato R, Bonelli A, Ponti J, Farina M, Bergamaschi E, Sabbioni E, Migliore L. Comparative genotoxicity of cobalt nanoparticles and ions on human peripheral leukocytes in vitro. Mutagenesis. 2008 Sep;23(5):377-82. Epub 2008 May 25.
