Structure de mise en forme 2 colonnes

Institut Polytechnique de Bordeaux - LCPO

LCPO (Laboratoire de Chimie des Polymères Organiques) is a public laboratory affiliated to University of Bordeaux, CNRS and Institut Polytechnique de Bordeaux (IPB-ENSCBP). LCPO has a worldwide recognized expertise in polymer synthesis, green chemistry, macromolecular engineering and self-assembly towards the development of functional materials for organic electronics and biomedical applications. The “Polymer Nanotechnology for Life Science” group is involved in Nanother project.

 

Contact

Sébastien Lecommandoux
Professor at the ENSCBP-University of Bordeaux
Member of the Institut Universitaire de France (IUF)
Laboratoire de Chimie des Polymères Organiques (LCPO), UMR CNRS 5629
16 Avenue Pey Berland
33607 PESSAC cedex, FRANCE
Tel: +33(0) 5 40 00 22 41
Fax: +33(0) 5 40 00 84 87
lecommandoux@enscbp.fr

 

Role/activity of organisation in the project

The role of LCPO in NanoTher consists in designing new drug delivery systems to convey the chosen anticancer drugs toward their target by surface functionalization with peptides or antibodies. Specific amphiphilic polypeptide-based block copolymers are designed and synthesized. Hybrid copolymer nanoparticles (HCNPs) are formulated by nano-precipitation with anticancer drugs or biomolecules (siRNA, peptides, anthracylin molecules), and magnetic nanoparticles (iron oxides). Drug loading and release, colloidal characterization, stability in biological media and antibody bioconjugation are studied using the most advanced physico-chemistry tools.

 

Pr. Sébastien Lecommandoux is a recognized expert in the design of polypeptide and polysaccharide based block copolymers for self-assembly into stimuli-responsive polymersomes, their drug loading and release, formation of magnetic hybrids and their physico-chemistry characterization.

Pr. Alain Brisson is a professor at University of Bordeaux and IECB group leader with recognized contributions in the fields of biological membrane biophysics and nanobiotechnology, with major expertise in Cryo-TEM, AFM and protein functionalization of liposomal and polymeric nanovectors.

Dr. Jean-François Le Meins is an assistant professor who developed an activity on the synthesis and self-assembly of block copolymers based on polysaccharides and more recently on the modulation of polymersomes’ membranes properties.

Dr. Elisabeth Garanger, after a post-doc in Harvard Medical School on multi-modal imaging probes, worked in the NanoTher project in 2009-2010 before joining IECB as project leader on the design of HCNPs based on solid or recombinant synthesis of peptides.

Dr. Hugo De Oliveira is a post-doctoral fellow who joined the team at the end of 2010, after his thesis on the field of non-viral targeted gene delivery vectors applied to the peripheral nervous system, developed in INEB, Portugal, and started to work on the biofunctionalization of the HCNPs.

Dr. Olivier Sandre is a CNRS researcher previously working at UPMC in Paris on polymeric systems doped with magnetic nanoparticles collaborating with LCPO since 2003, who joined the team in April 2010.

Dr. Julie Thévenot is a post-doctoral fellow who got her thesis on lipid-polymer particle assemblies in the joint research unit of Biomérieux, CNRS and Université Lyon 1 and optimized most of the experimental protocols for the synthesis of the copolymers and the formulation of the HCNPs used in NanoTher.

Dr. Christophe Schatz is an assistant professor who developed polymersomes for gene delivery, able to encapsulate and deliver drugs or large molecules (siRNA) upon pH decrease.

Stéphanie Louguet is a PhD student who will defend her thesis in 2011 on HCNPs for temperature controlled drug release under hyperthermia and MRI.

Yali Wan is a PhD student, whose PhD thesis focuses on the development of protein functionalized nanovectors for drug delivery, including polymeric and magnetic nanoparticles.

Recent publications / patents

Publications:

[1] K. K. Upadhyay, J.-F. Le Meins, A. Misra, P. Voisin, V. Bouchaud, E. Ibarboure, C. Schatz , S. Lecommandoux, Biomimetic Doxorubicin Loaded Polymersomes from Hyaluronan-block-poly(benzyl glutamate) copolymers. Biomacromolecules 2009, 10, 2802–2808 doi: 10.1021/bm9006419
[2] C. Schatz, S. Louguet, J.F Le Meins, S. Lecommandoux, Polysaccharide-block-Polypeptide Copolymer Vesicles: Towards Syntheticviral Capsids  Angewandte Chemie International edition 2009, 48, 2572–2575 doi: 10.1021/la902786t
[3] C. Sanson, C. Schatz, J.-F. Le Meins, A. Brûlet, A. Soum, S. Lecommandoux, Biocompatible and Biodegradable Poly(trimethylene carbonate)-b-Poly (L-glutamic acid) Polymersomes: Size Control and Stability. Langmuir 2010, 26, 2751–2760.
[4] K.K Upadyay, A. N Bhatt, A.K Mishra, B. S. Dwarakanath, S. Jain, C. Schatz, J.-F. Le Meins, A. Farooque, G. Chandraiah, A. K Jain , A. Misra, S. Lecommandoux. The Intracellular Drug Delivery and Anti Tumor Activity of Doxorubicin Loaded Poly(-benzyl L-glutamate)-b-Hyaluronan Polymersomes. Biomaterials 2010, 31, 3882–3892 10.1016/j.biomaterials.2009.12.043
[5] K.K Upadyay, A. N Bhatt, E. Castro, A.K Mishra, K. Chuttani, B. S. Dwarakanath, C. Schatz, J.-F. Le Meins, A. Misra, S. Lecommandoux, In vitro and In vivo Evaluation of Docetaxel Loaded Biodegradable Polymersomes, Macromolecular Bioscience 2010, 10, 503–512, doi: 10.1002/mabi.200900415
[6] C. Sanson, J.-F. Le Meins, C. Schatz, A. Soum, S. Lecommandoux, Temperature Responsive Poly(trimethylene carbonate)-block-Poly(L-glutamic acid) Copolymer: Polymersomes Fusion and Fission. Soft Matter 2010, 6, 1722–1730  doi: 10.1039/b924617g
[7] C. Sanson, C. Schatz, J.-F. Meins, A. Soum, E. Garanger, J. Thévenot, S. Lecommandoux, A Simple Method to Achieve High Doxorubicin Loading in Biodegradable Polymersome. Journal of Controlled Release 2010, 147, 428–435 doi: 10.1016/j.jconrel.2010.07.123
[8] C. Sanson, O. Diou, J. Thévenot, E. Ibarboure, A. Soum, A. Brûlet, S. Miraux, E. Thiaudière, S. Tan, A. Brisson, V. Dupuis, O. Sandre, S. Lecommandoux, Doxorubicin-Loaded Magnetic Polymersomes: Multifunctional Nanocarriers for Theranostic Applications. ACS Nano 2011, published on-line doi: 10.1021/nn102762f
 


To top