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The INSTM was established in 1992 as a Consortium of Italian Universities with the goal to promote research activities in the field of Chemistry of Materials. Later it was joined by other similar Institutions and expanded its interests to the Science and Technology of Materials. The acronym INSTM stands for Consortium of Italian Universities for the Science and Technology of Materials. Nowadays it groups 45 Italian Universities, in practice all the Universities where research on Materials is carried out.

Role & Activities of the organisation in the project

Synthesis and characterisation of organic/hybrid drug loaded nanoparticles and conjugation of the targeting moieties to the synthesised organic/hybrid nanoparticles. Magnetic characterization of hybrid nanoparticles at different stages with particular regard to the parameters influencing the magnetization dynamics

Key people involved in the project

Emo Chiellini (University of Pisa), Full Professor of Chemical Fundamentals of Technologies at the Faculty of Engineering of the University of Pisa - Head of the Bioactive Polymeric Materials for Biomedical and Environmental Applications Laboratory (BIOlab). Prof. Chiellini is active in the field of Polymer Science & Technology since more than 40 years. Particular attention has been devoted to the preparation and characterisation of multifunctional polymers for biomedical, pharmaceutical and environmental applications.

Rolando Barbucci (University of Siena), Full Professor of Chemistry, Director of the Centro Interuniversitario Sistemi Medici Avanzati (C.R.I.S.M.A.), Coordinator of the second level Master on Biomaterials of the Faculty of Pharmacy. Experience based on biomacromolecules in particular on polysaccharides both natural and semisynthetic for biomedical application

Andrea Caneschi (University of Florence), Associate professor, in charge of the PhD and post-doc students, of the scientific management of all the contracts and projects and of the chemical part of the research. Inorganic chemistry, magnetic nanoparticles, magnetic interactions in metal ions, synthesis of organic radicals, magnetic molecular materials, synthesis of ligand to graft molecules on metal surfaces.

Paolo Ferruti (University of Milan), Full professor of Polymer Chemistry active for more than 40 years. Functionalisation of polymers, with special emphasis on synthesis and characterisation of biocompatible and biodegradable multifunctional polymers for medical application and as complexing agents for heavy metal ions.

Alessandro Lascialfari (University of Milano) Associate professor, in charge of post-laurea and post-doc students, of the scientific management of national projects and local management of international projects. Responsible of more than 15 proposals to international facilities (1993-current year). NMR and MUSR experiences in USA (Ames-Iowa State University), ISIS-RAL laboratory (UK), PSI (Switzerland), LCMI-CNRS (France) - research in the field of Condensed Matter Physics using calorimetry, Nuclear Magnetic Resonance (MRI) and Muon Spin Rotation as primary techniques.

Alfredo Ricci (University of Bologna) Full Professor at the Faculty of Industrial Chemistry of the University of Bologna. His research interests span the areas of target-oriented organic synthesis, organometallic chemistry, development of unconventional synthetic methodologies, metal-mediated catalysis and more recently organocatalysis and the chemistry of nanosized materials.


Recent publications & Patents

  • H. Amiri et al., 2011, Superparamagnetic Colloidal Nano-crystals coated with Polyethylene Glycol Fumarate Coated: a possible novel theranostic agent, Nanoscale DOI: 10.1039/C0NR00603C
  • R. Barbucci, et al., 2011, Chemical and biological properties of polysaccharide coated nanoparticles: the key role of proteins, Biomacromolecus, in press
  • A.M. Piras et al. 2010, Polymeric nanoparticles for targeted release of conventional and macromolecular drugs (preparation and characterization aspects). Editor(s): Chaughule R.S. and Ramanujan R.V. Nanoparticles: Synthesis, Characterization and Applicatons 1, P.294-335
  • M. Comes Franchini et al., 2010, Bovine Serum Albumin-Based Magnetic Nanocarrier for MRI Diagnosis and Hyperthermic Therapy: A Potential Theranostic Approach Against Cancer, Small 6, P. 366
  • M. F. Casula et al., 2010, Magnetic Resonance Imaging Contrast Agents Based on Iron Oxide Superparamagnetic Ferrofluids, Chem. Mater. 22, P.1739
  • Comes Franchini, A. Ricci et al. Small, 2010, P.366-370.
  • M. F. Casula et al. 2010, Magnetic Resonance Imaging Contrast Agents based on Iron Oxide Superparamagnetic Ferrofluids,. Mater., 22, P.1739
  • E. Chelebaeva et al., 2010, Mesoporous silica nanoparticles combining two-photon excited fluorescence and magnetic properties, J. Mater. Chem. 20, P.1877
  • A. Masotti et al., 2009, “Synthesis and characterization of polyethylenimine-based iron oxide composites as novel contrast agents for MRI, Magn Reson Mater Phy 22, P.77
  • P. Sánchez et al., 2009, MRI relaxation properties of water-soluble apoferritin-encapsulated gadolinium oxide-hydroxide nanoparticles, Dalton Transactions, P.800-804
  • L. Lartigue et al., 2009, Water-Soluble Rhamnose-Coated Fe3O4 Nanoparticles, Organic Letters 11, P.2992
  • A. Masotti et al. 2009, Synthesis and Characterization of Polyethylenimine-based Iron Oxide Composites as Novel Contrast Agents for MRI, , Magnetic Resonance Materials in Physics, Biology and Medicine 22, P. 77
  • A. Figuerola et al., 2008, “One-Pot Synthesis and Characterization of Size-Controlled Bimagnetic FePt-Iron Oxide Heterodimer Nanocrystals, J. Am. Chem. Soc. 130, P.1477
  • M. Corti et al., 2008, Magnetic properties of novel superparamagnetic MRI contrast agents based on colloidal nanocrystals, J. Magn. Magn. Mater. 320, P.e320
  • A Boni et al., 2008, Magnetic and relaxometric properties of Mn ferrites, J. Phys. D: Appl. Phys. 41, P.134021
  • Y. Guari et al., 2008, Cyano-bridged coordination polymer nanoparticles with high nuclear relaxivity: toward new contrast agents for MRI, Dalton Trans. 28, P.3658
  • F. Chiellini et al., 2008, Micro/nanostructured polymeric systems for biomedical and pharmaceutical applications. Nanomedicine 3(3), P.367-93.
  • A.M. Piras et al. 2008, Polymeric nanoparticles for hemoglobin-based oxygen carriers, Biochimica et Biophysica Acta - Proteins and Proteomics. 1784(10), P.1454-61.
  • F. Chiellini et al. 2008, Bioactive polymeric materials for targeted administration of active agents: Synthesis and evalution, Macromolecular Bioscience. 8(6), P.516-25.
  • A.M. Piras et al. 2008, A new biocompatible nanoparticle delivery system for the release of fibrinolytic drugs, Int J Pharm. 357(1-2), P.260-71.
  • G. Baldi et al. 2007, Cobalt-Ferrite Nanoparticles: The control of the average size and surface state and their effects on magnetic properties, J. Magn. Magn. Mater. 311 , P.10-16.
  • G Baldi, M. Comes Franchini et al, 2007, Synthesis and Coating of Cobalt-Ferrite Nanoparticles:a First Step Towards the Obtainment of New Magnetic Biocarriers, Langmuir, P.4026-4028
  • N. Ashammakhi et al. 2007, Biodegradable Nanomats Produced by Electrospinning: Expanding Multifunctionality and Potential for Tissue Engineering, J. Nanosci. Nanotech. 7(3), P.862-882.
  • A. Lascialfari et al., 2007, Basic concepts of Magnetic Resonance Imaging, in “NMR-MRI, SR and Mössbauer spectroscopies in molecular magnets”, eds. P. Carretta, A. Lascialfari, Spinger-Verlag.
  • P. Ferruti et al. 2006, Novel Polyamidoamine-Based Hydrogel with an Innovative Molecular Architecture as a Co2+-, Ni2+-, and Cu 2+-Sorbing Material: Cyclovoltammetry and Extended X-Ray Absorption Fine Structure Studies, Journal of Polymer Science: Part A: Polymer Chemistry 44, P.2316–2327.
  • M. Comes Franchini et al, 2006, Nanoparticelle funzionalizzate, loro produzione ed uso. Italian Patent. 2006. n° FI2006A000006.
  • E. Chiellini et al, 2006, Bioerodible Polymeric Nanoparticles for Targeted Delivery of Proteic Drugs. J. Nanosci. Nanotech. 6, P.3040-3047
  • C. Altavilla et al., 2005, A New Route to Fabricate Monodisperse Magnetite Nanoparticles Monolayer on Silicon, Adv. Mater. 17, P.1084
  • A.Lascialfari, et al., 2005, Multiexponential T2-relaxation analysis in cerebrally damaged rats in the absence and presence of a gadolinium contrast agent, Mag.Res.Med. 53, P.1326.

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